Embryonic adipose development and consequences in later life

Volume 8, Issue 5, October 2023     |     PP. 118-137      |     PDF (573 K)    |     Pub. Date: October 18, 2023
DOI: 10.54647/biology180324    62 Downloads     134606 Views  

Author(s)

Joseph M. Schulz, Molecular Developmental and Cell Biology (MDB) Graduate Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Alejandro Tamayo Garcia, Molecular Developmental and Cell Biology (MDB) Graduate Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Chloe Muriel Bell Moulin, Molecular Developmental and Cell Biology (MDB) Graduate Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Isabella Delia Altilio Bove, Molecular Developmental and Cell Biology (MDB) Graduate Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Xiang-Xi (Mike) Xu, Molecular Developmental and Cell Biology (MDB) Graduate Program, University of Miami Miller School of Medicine, Miami, FL 33136, USA

Abstract
Adipose tissues distribute throughout the mammalian organs, though large deposits localize at specific anatomical sites, such as visceral, subcutaneous, intermuscular, and intramuscular fats. The embryonic origin of adipose tissues has been mapped using genetic mutant mice, and multiple lineages of adipose progenitor cells are recognized. We review literature for evidence of a population of embryonic adipose progenitor cells that develop in response to the abundance of caloric supplies. This adipocyte population of embryonic or juvenal origin is a likely candidate of adipocytes accounting for obesity and metabolic pathology in adults. Thus, we suggest a mechanism underlying early caloric excess impacts on obesity and metabolic problems later in adults.

Keywords
adipocyte, progenitor cells, embryonic development, metabolism, Dab2

Cite this paper
Joseph M. Schulz, Alejandro Tamayo Garcia, Chloe Muriel Bell Moulin, Isabella Delia Altilio Bove, Xiang-Xi (Mike) Xu, Embryonic adipose development and consequences in later life , SCIREA Journal of Biology. Volume 8, Issue 5, October 2023 | PP. 118-137. 10.54647/biology180324

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